Composition and manufacture of topical pharmaceutical and cosmetic semi-solid post-foaming dosage forms in a pouch

Abstract

A pouch containing a non-pressurized post-foaming gel, wherein the gel within the pouch is enclosed within an inert atmosphere, such as a nitrogen blanket, which protects the gel and prevents premature foaming and the separation of the gel's components. Upon opening the pouch and discharging the contents, the heat of the user's skin allows a low boiling point hydrocarbon, such as isopentane, to cause the gel to foam, thus providing the consumer with an instant benefit which could include cleansing, moisturizing, increasing shave comfort, wound treatment, etc. Further, the process to produce a gel which is suitable for use in a single use delivery system involves the steps of containing the gel in a jar, spraying the gel with nitrogen to remove the air from the jar, and then swirling the jar to form a non-aerated gel without weight variation problems.