The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2002
Filed:
Jul. 29, 1999
Claus Koster, Lilienthal, DE;
Jochen Franzen, Bremen, DE;
Bruker Daltonik GmbH, Bremen, DE;
Abstract
The invention relates to ionization with low fragmentation and adduct formation, of high-molecular analyte molecules, particularly of large biopolymers, by matrix-assisted laser desorption (MALDI) from liquid matrices for mass-spectrometric analysis of the resulting ions, particularly for determination of their molecular weight. The invention uses liquids as matrix substances with very low vapor pressures from the group of minimally trihydroxylic alcohols with at least one ether bond (ether polyols or polyether polyols). These can be used advantageously for energy absorption and ionization by infrared lasers (IR-MALDI), however other lasers, such as conventional. UV lasers, can be used for other wavebands by the addition of light-absorbing compounds.