The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2002
Filed:
May. 02, 2001
Applicant:
Inventors:
Timothy J. Martins, Bothell, WA (US);
Kerry W. Fowler, Seattle, WA (US);
Joshua Odingo, Everett, WA (US);
Edward A. Kesicki, Bothell, WA (US);
Amy Oliver, Bothell, WA (US);
Laurence E. Burgess, Boulder, CO (US);
John J. Gaudino, Boulder, CO (US);
Zachary S. Jones, Westminster, CO (US);
Bradley J. Newhouse, Broomfield, CO (US);
Stephen T. Schlacter, Boulder, CO (US);
Assignee:
ICOS Corporation, Bothell, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/1535 ; A61K 3/144 ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/1535 ; A61K 3/144 ; C07D / ; C07D / ;
Abstract
Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.