The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2002
Filed:
Sep. 19, 2000
Paolo Cozzi, Milan, IT;
Pier Giovanni Baraldi, Ferrara, IT;
Italo Beria, Villamarzana, IT;
Marina Caldarelli, Milan, IT;
Laura Capolongo, Milan, IT;
Romeo Romagnoli, Ferrara, IT;
Pharmacia & Upjohn, S.p.A., Milan, IT;
Abstract
Compounds which are benzoheterocyclic distamycin derivatives of formula (I), wherein n is 2, 3 or 4; A is a heteroatom selected from O and S or is a group NR, wherein R is hydrogen or C -C alkyl; B is CH or N; R is hydrogen or C -C alkyl; G is selected from the group consisting of (a, b, c, d, e, f, g, h, i, j), and —C≡N; wherein R , R , R , R , R , R , R and R are, independently from each other, hydrogen or C -C alkyl; T is a group of formula (II) or (III) as defined above, wherein p is 0 or 1; R and R are, independently from each other, hydrogen, C -C alkyl optionally substituted by one or more fluorine atoms, or C -C alkoxy; R is C -C alkyl or C -C haloalkyl; X and X are halogen atoms or pharmaceutically acceptable salts thereof; provided that at least one of R , R and R is alkyl; are useful as antitumor agents.