The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2002
Filed:
Apr. 16, 1999
Frank Dean, New York, NY (US);
Michael E. O'Donnell, Hastings-on-Hudson, NY (US);
The Rockefeller University, New York, NY (US);
Abstract
The present invention relates to isolated DNA molecules encoding mammalian single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway. Expression systems and host cells containing those DNA molecules as well as the proteins themselves and antibodies raised against them are also disclosed. The DNA molecules, proteins, and antibodies can be used for diagnostic purposes, while the DNA molecules also have therapeutic utility. In addition, transgenic animals can be produced where the gene encoding a single strand gap response protein is disrupted or deleted. As a result, these animals are characterized by spontaneous tumor development.