The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2002
Filed:
Sep. 27, 2000
Applicant:
Inventors:
Brian Kobilka, Palo Alto, CA (US);
Tae Weon Lee, Palo Alto, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/700 ; G01N 3/358 ;
U.S. Cl.
CPC ...
C07K 1/700 ; G01N 3/358 ;
Abstract
The present invention provides modified G protein &agr;-subunits which are characterized by constitutive localization to the plasma membrane; enhanced binding to one or more of the normal receptor binding partners for that &agr;-subunit; and efficient binding to and activation of G protein binding partners. The distribution of these modified &agr;-subunits, which are “tethered” to the plasma membrane, allows the regulation of receptor-G protein coupling, and thus G-protein signaling, in various biological systems.