The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2002
Filed:
Mar. 16, 2001
Mark David Andrews, Kent, GB;
David Hepworth, Kent, GB;
Donald Stuart Middleton, Kent, GB;
Alan Stobie, Kent, GB;
Pfizer Inc., New York, NY (US);
Abstract
A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein; R and R , which may be the same or different, are hydrogen, C -C alkyl, (CH ) (C -C cycloalkyl) wherein m =0, 1, 2 or 3, or R and R together with the nitrogen to which they are attached form an azetidine ring; each R is independently CF , OCF , C alkylthio or C -C alkoxy; n is 1, 2 or 3; and R and R , which may be the same or different, are: A—X, wherein A =—CH=CH— or —(CH )p— where p is 0, 1 or 2; X is hydrogen, F, Cl, Br, I, CONR R , SO NR R , SO NHC(=O)R , OH, C alkoxy, NR SO R , NO , NR R , CN, CO R , CHO, SR , S(O)R or SO R ; R , R , R and R which may be the same or different, are hydrogen or C alkyl optionally substituted independently by one or more R ; R is C alkyl optionally substituted independently by one or more R ; R is hydrogen, C alkyl optionally substituted independently by one or more R , C(O)R , CO R , C(O)NHR or SO NR R ; R is F, OH, CO H, C cycloalkyl, NH , CONH , C alkoxy, C alkoxycarbonyl or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O optionally substituted independently by one or more R ; or R and R , together with the nitrogen to which they are attached, form a 4-, 5- or 6-membered heterocyclic ring optionally substituted independently by one or more R ; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R ; wherein R is hydroxy, C -C alkoxy, F, C -C alkyl, haloalkyl, haloalkoxy, —NH , —NH(C -C alkyl) or —N(C -C alkyl) ; wherein when R and R are methyl, R and R are hydrogen and n is 1, R is not a —SMe group para to the ether linkage linking rings A and B.