The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2002

Filed:

Nov. 01, 2000
Applicant:
Inventors:

Peter Krulevitch, Pleasanton, CA (US);

Harold D. Ackler, Sunnyvale, CA (US);

Frederick Becker, Houston, TX (US);

Bernhard E. Boser, Berkeley, CA (US);

Adam B. Eldredge, Austin, TX (US);

Christopher K. Fuller, Livermore, CA (US);

Peter R. C. Gascoyne, Bellaire, TX (US);

Julie K. Hamilton, Tracy, CA (US);

Stefan P. Swierkowski, Livermore, CA (US);

Xiao-Bo Wang, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 2/700 ; G01N 3/3543 ; G01R 2/728 ;
U.S. Cl.
CPC ...
G01N 2/700 ; G01N 3/3543 ; G01R 2/728 ;
Abstract

A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.


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