The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2002
Filed:
Nov. 01, 2000
Graham Richard Geen, Dunmow, GB;
Andrew Colin Share, Saffron Walden, GB;
Novartis International Pharmaceutical Ltd., Hamilton, BM;
Abstract
The invention provides a method of rearranging a compound of formula (I), wherein R and R′ are selected independently from hydrogen and C alkyl; and R and R are selected independently from hydrogen, hydroxy, halo, C alkyl- or aryl carbonate, amino, mono- or di-C alkylamino, C alkyl or arylamido, C alkyl- or arylcarbonyl, C alkyl- or arylcarboxy, C alkyl- or arylcarbamoyl, C alkyl, C alkenyl, C alkynyl, aryl, heteroaryl, C alkoxy, aryloxy, azido, C alkyl- or arylthio, C alkyl- or arylsulfonyl, C alkyl- or arylsilyl, C alkyl- or arylphosphoryl, and phosphato; to form a compound of formula (II), wherein R, R′, R and R are as defined for formula (I); said method comprising treating the compound of formula (I) with a palladium (0) catalyst and a (diphenylphosphino) C alkane, wherein n is an integer of 1-6. The invention also provides methods of R making penciclovir and famciclovir using this rearrangement reaction.