The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2002
Filed:
Oct. 01, 1999
Applicant:
Inventors:
Jan Domin, London, GB;
Michael Derek Warerfield, London, GB;
Assignee:
Ludwig Institute for Cancer Research, Zurich, CH;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 2/106 ;
U.S. Cl.
CPC ...
C12P 2/106 ;
Abstract
The invention relates to a novel human class II PI3-kinase and in particular the sequence of the isolated nucleic acid molecule and the encoded amino acid sequence. The novel human PI3-kinase is termed PI3K-C2&agr; and has unique biochemical properties that characterize and distinguish it from known PI3-kinases. These include, amongst other things, resistance to the PI3-kinase inhibitors Wortmannin and LY294000, the lack of a p85 binding site, a divergent amino terminus and the absence of a polyproline motif which is typical of known type II PI3-kinases.