The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2002

Filed:

Sep. 14, 1999
Applicant:
Inventors:

Mitchel J. Doktycz, Knoxville, TN (US);

Charles L. Britton, Jr., Alcoa, TN (US);

Stephen F. Smith, Loudon, TN (US);

Patrick I. Oden, Plano, TX (US);

William L. Bryan, Knoxville, TN (US);

James A. Moore, Powell, TN (US);

Thomas G. Thundat, Knoxville, TN (US);

Robert J. Warmack, Knoxville, TN (US);

Assignee:

U T Battelle, LLC, Oak Ridge, TN (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 2/520 ;
U.S. Cl.
CPC ...
G01N 2/520 ;
Abstract

A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.


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