The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2002
Filed:
Apr. 03, 2000
Applicant:
Inventors:
Charles A. Lesburg, Weehawken, NJ (US);
Michael Cable, Freehold, NJ (US);
Zhi Hong, Nanuet, NY (US);
Anthony F. Mannarino, North Plainfield, NJ (US);
Patricia C. Weber, Yardley, PA (US);
Assignee:
Schering Corporation, Kenilworth, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 3/348 ; G01N 3/350 ; C12N 9/00 ;
U.S. Cl.
CPC ...
G01N 3/348 ; G01N 3/350 ; C12N 9/00 ;
Abstract
The invention relates to the purification, crystallization of and structure of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. Also, crystallization conditions for NS5B are provided. Further, the atomic coordinates for the NS5B protein are disclosed. Examples of its use for the determination of the three-dimensional atomic structures of HCV NS5B or HCV NS5B in complex with substrates or substrate analogs or inhibitors are also provided.