The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 13, 2002
Filed:
Nov. 25, 1998
Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
Applicant:
Inventors:
Ann B. Zimrin, Marriottsville, MD (US);
Michael Wong, Derwood, MD (US);
Thomas Maciag, Freeport, ME (US);
Michael S. Pepper, Geneva, CH;
Roberto Montesano, Geneva, CH;
Assignee:
Maine Medical Center Research Institute, Scarborough, ME (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/817 ; C07K 1/4435 ;
U.S. Cl.
CPC ...
A61K 3/817 ; C07K 1/4435 ;
Abstract
This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof.