The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2002
Filed:
Sep. 14, 2001
Byron H. Arison, Watchung, NJ (US);
Donghui Cui, Newtown, PA (US);
Mark E. Duggan, Schwenksville, PA (US);
Wasyl Halczenko, Lansdale, PA (US);
John H. Hutchinson, Philadelphia, PA (US);
Thomayant Prueksaritanont, Lansdale, PA (US);
Raju Subramanian, Perkasie, PA (US);
Xiaojun Fang, Kalamazoo, MI (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention relates to novel compounds formed by metabolic conversion of compounds of structural formula (1), pharmaceutical compositions containing such compounds, and their use as &agr;v&bgr;3 integrin receptor antagonists. The compounds of the present invention are useful for inhibiting bone resorption, restenosis, angiogenesis, diabetic retinopathy, macular degeneration, inflammatory arthritis, cancer, and metastatic tumor growth. They are particularly useful for inhibiting bone resorption and for the treatment and prevention of osteoporosis.