The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 30, 2002
Filed:
Aug. 14, 1998
Kenneth Loren Beattie, The Woodlands, TX (US);
Other;
Abstract
The present invention provides an improved method for stably attaching a desired compound to a silaceous or silane-containing substrate, in particular a glass, porous silica, or oxidized silicon. This method in certain embodiments provides improvements over conventional methods for attaching desired compounds to silaceous or silane-containing substrate, e.g., glass, porous silica, or oxidized silicon materials, e.g. obviating the need for derivatization (e.g., epoxysilane derivatization) prior to attachment. More particularly, the present invention provides a method for stably attaching a desired compound comprising at least one amine and hydroxyl group (e.g., an aminopropanol containing compound), to a silaceous or silane-containing substrate, preferably underivatized (plain) glass, a porous silica, or oxidized silicon substance. The subject method is especially useful for the attachment of nucleic acid sequences, e.g., oligonucleotide or PCR generated DNA fragments, to glass or other silane-containing substrates to which is stably attached to a desired compound, is useful in any application wherein a compound immobilized to a substrate, e.g., a glass, is useful. Such applications include, by way of example, hybridization analysis, DNA purification, immunoassay, and immunopurification methods.