The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2002
Filed:
Feb. 01, 2001
Shiro Mita, Osaka, JP;
Masato Horiuchi, Osaka, JP;
Masakazu Ban, Osaka, JP;
Hiroshi Suhara, Osaka, JP;
Santen Pharmaceutical Co., Ltd., Osaka, JP;
Abstract
An object of the present invention is to provide novel urea derivatives which have TNF-&agr; production inhibitory effects and are useful as therapeutic agents for various diseases, particularly as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. The urea derivatives according to the present invention are compounds represented by the formula [I] and salts thereof. In the formula, R is H, alkyl, phenyl or a group of the formula [`I]; R is H, alkyl, carboxyl or ester thereof or the like; R and R are each H, alkyl, cycloalkyl or the like; R is H, alkyl, hydroxy or the like; R is a nitrogen aromatic heterocycle; and A and A are alkylene.