The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2002
Filed:
Dec. 18, 2000
Applicant:
Inventors:
Manfred Weigele, Cambridge, MA (US);
David C. Dalgarno, Brookline, MA (US);
John Iuliucci, Andover, MA (US);
Terence P. Keenan, Cambridge, MA (US);
Tomi K. Sawyer, Southborough, MA (US);
Assignee:
Ariad Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K 3/144 ;
U.S. Cl.
CPC ...
C07D / ; A61K 3/144 ;
Abstract
Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone targeting moiety and a payload. The payload portion of these inventive compounds inhibit the proton pump of osteoclasts, thereby, reducing bone resorption. Compounds of the present invention include compounds of the following formula: