The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2002
Filed:
Feb. 16, 1996
Applicant:
Inventors:
Richard Bucala, New York, NY (US);
Peter C. Ulrich, Old Tappan, NJ (US);
Xini Xhang, Jericho, NY (US);
Anthony Cerami, Shelter Island, NY (US);
Assignee:
The Picower Institute for Medical Research, Manhasset, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 3/353 ; C07D / ;
U.S. Cl.
CPC ...
G01N 3/353 ; C07D / ;
Abstract
The present invention encompasses assays to identify compounds that inhibit the enzymatic activity of MIF which catalyzes the tautomerization of MIF-substrates, such as D-dopachrome to DHICA. In general, the assay is conducted in vitro by adding, mixing or combining MIF and a suitable substrate in the presence or absence of a test compound, and measuring the tautomerization of the substrate. The test compounds that inhibit tautomerization in the assay are identified as MIF inhibitors.