The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2002
Filed:
Jun. 29, 2000
Applicant:
Inventors:
Carl W. Porter, East Aurora, NY (US);
Slavoljub Vujcic, Amherst, NY (US);
Debora Kramer, East Aurora, NY (US);
Kristen Kee, Kenmore, NY (US);
Assignee:
Health Research, Inc., Buffalo, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/587 ; C12Q 1/68 ; C12P 1/934 ; C07K 1/700 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/587 ; C12Q 1/68 ; C12P 1/934 ; C07K 1/700 ; C07H 2/104 ;
Abstract
The present invention provides a novel method to increase both the antitumor potency and the selectivity of DENSPM, a polyamine analog. The method comprises the steps increasing the amount of SSAT mRNA, and delivering a therapeutically sufficient dose of DENSPM which allows conversion of SSAT mRNA to enzyme activity, polyamine pool depletion and growth inhibition. The SSAT mRNA may be increased by conditionally induced overexpression of SSAT, or by modulating the transcriptional regulation of the endogenous SSAT gene.