The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 2002
Filed:
Aug. 25, 2000
Andres J. Garcia, Philadelphia, PA (US);
Paul Ducheyne, Rosemont, PA (US);
David Boettiger, Philadelphia, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Non-crystalline, porous bioactive glass and ceramic materials are prepared that permit in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells. The bioactive glass and ceramic materials are treated such that when used in contact with anchorage-dependent cells, there is enhanced cell attachment and cell function to provide expeditious tissue growth in vitro or in vivo. Treatment involves immersing the glass or ceramic material in an aqueous solution containing ions in a concentration typical of interstitial fluid followed by immersion in an aqueous solution containing at least one cell adhesion molecule. Immersion may also be in an additional aqueous solution containing an additional cell adhesion molecule before or after immersing in the solution containing ions. The glass material is preferably formed from SiO , CaO, Na O and P O . The glass material is preferably prepared by melting constituents, cooling and pulverizing the resultant glass to obtain a powder, and then forming and hot pressing the powder. The glass may be formed to produce templates, a swell as to produce granules that may be formed into a paste. An implant may be formed by coating an implant material with the treated bioactive glass or ceramic material.