The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 2002

Filed:

Jan. 16, 2001
Applicant:
Inventors:

Holger Heitsch, Mainz-Kastel, DE;

Heinrich Christian Englert, Hofheim, DE;

Heinz Gögelein, Frankfurt am Main, DE;

Assignee:

Aventis Pharma Deutschland GmbH, Frankfurt am Main, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/144 ; A61K 3/138 ; A61K 3/134 ; A61K 3/1175 ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/144 ; A61K 3/138 ; A61K 3/134 ; A61K 3/1175 ; C07D / ;
Abstract

Novel 2,5-substituted benzolsulfonyl ureas and thioureas of formula (I) as illustrated in the disclosure. The compounds are useful active ingredients for medicaments. The compounds of formula (I) act as inhibitors on ATP-sensitive potassium canals and are suitable for the treatment of cardiovascular disorders, especially the treatment of arrhythmias, prevention of sudden death from heart disease or affect diminished contractility of the heart. The invention also relates to methods for producing compounds of formula (I), the use thereof and pharmaceutical preparations containing said compounds.


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