The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2002
Filed:
Mar. 24, 2000
Jean-Claude Arnould, Reims, FR;
Other;
Abstract
The present invention relates to a compound of Formula (1) wherein Ar represent (A) or (B) or (C); R is hydrogen, C alkyl or C alkanoyl; R and R are independently hydrogen or C alkyl; Ar is phenyl or heteroaryl; p is 0 or 1; Ar is of formula (I) wherein W, X, Y and Z are independently CH or N, provided that at least two of W, X, Y and Z are CH and R and —(CH ) R are attached to ring carbon atoms; R is a group of Formula (II) or R represents a lactone of Formula (III) the group of Formula (II) or (III) having L or D configuration at the chiral alpha carbon in the corresponding free amino acid; n is 0, 1 or 2; R is phenyl or heteroaryl; provided that: when n is 0, Ar is substituted by R in the 4-position and —(CH ) R in the 3- or 5-position; and when n is 1 or 2, Ar is substituted by R in the 3- or 5-position and —(CH ) R in the -position; and R -R , m and n are as defined in the specification; or a pharmaceutically-acceptable salt, prodrug or solvate thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. A particular use is in cancer therapy.