The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2002
Filed:
Nov. 07, 2000
Mark S Jensen, Holmdel, NJ (US);
Michael Palucki, Belle Mead, NJ (US);
Nelo R. Rivera, Scotch Plains, NJ (US);
Kenneth M. Wells, Neshanic Station, NJ (US);
Yi Xiao, Fanwood, NJ (US);
Yaling Wang, Westfield, NJ (US);
Chunhua Yang, Edison, NJ (US);
Nobuyoshi Yasuda, Mountainside, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
A novel process is provided for the preparation of imidazolidinone &agr;v&bgr;3/&agr;v&bgr;5 integrin antagonists, and the useful intermediates obtained therein. These compounds are antagonists of &agr;v&bgr;3/&agr;v&bgr;5 integrin receptors and thus useful for inhibiting bone resorption and treating and preventing osteoporosis. Also disclosed is 3-{2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl)-propyl]imidazolidin-1-yl}-3(S)-(6-methoxy-pyridin-3-yl)-propionic acid in the form of a hemihydrate.