The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2002
Filed:
Nov. 29, 2000
Applicant:
Inventors:
Roy A. Black, Seattle, WA (US);
Charles Rauch, Bainbridge Island, WA (US);
Carl J. March, Bainbridge Island, WA (US);
Douglas P. Cerretti, Seattle, WA (US);
Assignee:
Immunex Corporation, Seattle, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/37 ; C12N 9/50 ; C12N 1/500 ; C12N 1/20 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12Q 1/37 ; C12N 9/50 ; C12N 1/500 ; C12N 1/20 ; C07H 2/104 ;
Abstract
A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.