The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2002
Filed:
Jun. 16, 1998
Applicant:
Inventor:
Emad S. Alnemri, Township Upper Dublin, County Montgomery, PA (US);
Assignee:
Thomas Jefferson University, Philadelphia, PA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/4435 ;
U.S. Cl.
CPC ...
C07K 1/4435 ;
Abstract
Truncated Apaf-1 nucleic acids and encoded polypeptides are provided. Also provided are self-oligomerizing caspase molecules capable of self-processing. In one embodiment the present invention provides methods for identifying apoptotic inhibitors and enhancers use whole cell or reconstituted component assay systems. In a further embodiment, truncated Apaf-1 and self-oligomerizing caspase constructs are described which can be provided to a cell, thereby inducing apoptosis.