The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 2002
Filed:
Sep. 11, 1998
Applicant:
Inventors:
Richard W Titball, Salisbury, GB;
Ethel D Williamson, Salisbury, GB;
Helen L Havard, Salisbury, GB;
Petra C F Oyston, Salisbury, GB;
Dean W Payne, Salisbury, GB;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/902 ; A61K 3/900 ; A61K 3/9385 ; A61K 3/908 ; C07K 1/00 ;
U.S. Cl.
CPC ...
A61K 3/902 ; A61K 3/900 ; A61K 3/9385 ; A61K 3/908 ; C07K 1/00 ;
Abstract
The present invention provides proteins for use in vaccines which are capable of inducing protective antibodies directed against epsilon toxin when administered to animals or man and thereby providing prophylaxis or therapy against infection by epsilon toxin. Particularly the present invention provides proteins which are based upon the mature toxin of the epsilon toxin gene, but which have a mutation such that the amino acid at position 106 is different to the wild-type sequence and their use in vaccine compositions.