The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2002
Filed:
Aug. 26, 1996
Masahiko Kinosaki, Tochigi, JP;
Kyoji Yamaguchi, Saitama, JP;
Fumie Kobayashi, Tochigi, JP;
Masaaki Goto, Tochigi, JP;
Akihiko Murakami, Tochigi, JP;
Masatsugu Ueda, Saitama, JP;
Yasushi Yamashita, Tochigi, JP;
Kanji Higashio, Saitama, JP;
Daiichi Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
The present invention relates to a TCF mutant having a novel amino acid sequence which is obtained by mutagenesis of one or more amino acid between N-terminus and the first kringle of the amino acid sequence of native TCF and has lowered affinity to heparin and/or elevated biological activity. The present TCF mutant is prepared by gene manipulation of TCF. The TCF mutants of the present invention have proliferative activity and/or growth stimulative activity in hepatocyte and beneficial as a therapeutic agent for various hepatic diseases and an antitumor agent.