The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2002
Filed:
Jan. 25, 2001
Applicant:
Inventors:
Assignee:
Biogal Gyogyszergyar Rt., Debrecen, HU;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01J 1/508 ; B01D 1/508 ; C12D 7/00 ; C12D 1/706 ; C07D / ;
U.S. Cl.
CPC ...
B01J 1/508 ; B01D 1/508 ; C12D 7/00 ; C12D 1/706 ; C07D / ;
Abstract
A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.