The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2002
Filed:
Jun. 24, 1999
Applicant:
Inventors:
Duy H. Hua, Manhattan, KS (US);
Jean-Pierre Perchellet, Manhattan, KS (US);
Assignee:
Kansas State University Research Foundation, Manhattan, KS (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/144 ; A61K 3/154 ; A61K 3/1535 ; A61K 3/1505 ; A61P 3/500 ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/144 ; A61K 3/154 ; A61K 3/1535 ; A61K 3/1505 ; A61P 3/500 ; C07D / ; C07D / ; C07D / ; C07D / ;
Abstract
This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple condensation reaction of pyrones with cyclohexenecarboxaldehydes, providing high yields and using few steps. The tetracyclic oxypyrone synthetic method is a simple condensation reaction of carvones with pyrones.