The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2002
Filed:
May. 18, 1999
Applicant:
Inventors:
Roy Curtiss, III, St. Louis, MO (US);
Cheryl A. Nickerson, River Ridge, LA (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/902 ; A61K 4/800 ; C12N 1/574 ; C12N 1/21 ;
U.S. Cl.
CPC ...
A61K 3/902 ; A61K 4/800 ; C12N 1/574 ; C12N 1/21 ;
Abstract
Attenuated immunogenic bacteria having an RpoS phenotype, in particular, serotype Typhi having an RpoS phenotype and methods therefor are disclosed. The Salmonella have in addition to an RpoS phenotype, an inactivating mutation in one or more genes which render the microbe attenuated, and a recombinant gene capable of expressing a desired protein. The Salmonella are attenuated and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for genes and gene products. Also disclosed are methods for preparing the vaccine delivery vehicles.