The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2002
Filed:
Apr. 21, 2000
Ales Prokop, Nashville, TN (US);
Mikhail M. Dikov, Nashville, TN (US);
Phillip Williams, Lebanon, TN (US);
Jeffrey M. Davidson, Nashville, TN (US);
Vanderbilt University, Nashville, TN (US);
Abstract
The present invention provides a convenient polymeric film or microparticulate vehicle to deliver protein factors into appropriate body sites to induce appropriate therapeutic effects. It also improves the existing methodologies for immunoisolation of non-human pancreatic islets (via microencapsulation) to protects them from the immunologically-different host. This invention demonstrates how vascularization and angiogenesis can be induced by means of addition of proper angiogenic factors. The angiogenesis is sustained over a long period of time, depending on the release characteristics of the polymeric matrix. Three-dimensional polymeric structures (mesh or perforated tubing and film) are used as resident materials for microcapsules bearing islets. Blood capillaries are generated outside the capsules and penetrate through the implant openings to ingrow into the vicinity of capsules/islets.