The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2002
Filed:
Dec. 31, 1999
Applicant:
Inventors:
Nnochiri Ekwuribe, Cary, NC (US);
Gary S. Bartley, Durham, NC (US);
Christopher H. Price, Chapel Hill, NC (US);
Assignee:
Nobex Corporation, Research Triangle Park, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K 3/1337 ;
U.S. Cl.
CPC ...
C07D / ; A61K 3/1337 ;
Abstract
The present invention generally provides taxane prodrugs comprising at least one taxane joined by hydrolyzable bond(s) to one or more polyethylene glycol oligomer(s) selected from the group consisting of a straight or branched polyethylene glycol oligomer having from 1 to 25 polyethylene glycol units and optionally comprising a salt-forming moiety. The polyethylene glycol oligomer preferably comprises a salt-forming moiety, which is preferably selected from the group consisting of ammonium and carboxylate.