The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 2002
Filed:
Dec. 01, 1999
Applicant:
Inventors:
Scott P. Bruder, Owings Mills, MD (US);
Neelam Jaiswal, Ellicott City, MD (US);
Assignee:
Osiris Therapeutics, Inc., Baltimore, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/02 ; C07K 1/600 ; A01N 6/300 ; A61K 3/9395 ;
U.S. Cl.
CPC ...
C12N 5/02 ; C07K 1/600 ; A01N 6/300 ; A61K 3/9395 ;
Abstract
Disclosed are compositions and methods for accelerating the differentiation of human MSCs into the osteogenic lineage with resultant enhanced de novo bone formation. This makes possible improved methods for bone defect repair. Thus, one aspect of the invention is a method for accelerating the differentiation of ALCAM-bearing hMSCs into the osteogenic lineage by contacting such hMSCs with a ligand that binds to activated leukocyte-cell adhesion molecule (ALCAM) on a single hMSC. Preferably, the ligand is a F fragment of a monoclonal antibody expressed by the hybridoma of ATCC Accession No. NB 11789.