The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2002
Filed:
May. 25, 2000
Applicant:
Inventors:
Dean Y. Li, Salt Lake City, UT (US);
Mark T. Keating, Salt Lake City, UT (US);
Assignee:
The University of Utah Research Foundation, Salt Lake City, UT (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01K 6/7027 ; A01K 6/700 ; C12N 1/500 ; C12P 2/100 ; G01N 3/300 ;
U.S. Cl.
CPC ...
A01K 6/7027 ; A01K 6/700 ; C12N 1/500 ; C12P 2/100 ; G01N 3/300 ;
Abstract
Transgenic mice are genetically engineered for a deficiency in endoglin production. These mice may have a homozygous or hemizygous disruption of the endogenous endoglin gene. Homozygous mice exhibit a lack of endoglin production. The failure to produce endoglin results in arrested development of the vascular system of the mouse and no survival beyond E11.5. These mice and cells derived therefrom provide useful reagents for understanding the development and pathology of the mammalian vascular system.