The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2002
Filed:
Apr. 12, 2001
Dennis P. Curran, Pittsburgh, PA (US);
Wu Du, Pittsburgh, PA (US);
University of Pittsburgh, Pittsburgh, PA (US);
Abstract
A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor under conditions to generate a silyl radical. SiR R R wherein R , R and R are independently a C alkyl group, a C alkenyl group, a C alkynyl group, an aryl group, —(CH ) R or SiR R R , wherein m is an integer within the range of 1 through 10 and R is a hydroxy group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, F, Cl, a cyano group, —SR or a nitro group, and wherein R , R and R are independently the same or different an alkyl group or an aryl group.