The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2002
Filed:
Nov. 23, 1998
Barry L. Karger, Newton, MA (US);
Wolfgang Goetzinger, Boston, MA (US);
Northeastern University, Boston, MA (US);
Abstract
Coatings suitable for surfaces such as are found in capillary electrophoresis columns and methods for their preparation are disclosed. A coated surface of the invention, preferably an interior surface of a microcapillary, generally includes a surface having an interconnected polymeric coating that includes a functional group attached to the surface and capable of copolymerizing with an organic compound in an organic solvent, and a polymer of the organic compound copolymerized with the functional group. The coating can be covalently or non-covalently attached to the surface and can further include an additional layer of coating material. Preferably, the organic compound is a vinyl ester, and most preferably, vinyl acetate, and the attached polymer forming the exposed surface of the coating is a polyvinyl alcohol, the hydroxyl groups of which can be further derivatized in any desired manner. The coating of the invention creates a new, stable surface, appropriate for CE columns or general surface modification. The coating is stable over a wide pH range and allows highly efficient grafting and/or adsorption of a variety of additional layers, if desired.