The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2002
Filed:
Apr. 19, 2000
Serhly Souchelnytskyi, Uppsala, SE;
Kiyoshi Tamaki, Uppsala, SE;
Ulla Engotröm, Uppsala, SE;
Christer Wornstedt, Uppsala, SE;
Ester Piek, Uppsala, SE;
Peter Bon Dijke, Uppsala, SE;
Carl-Henrik Heldin, Uppsala, SE;
Ludwig Institute for Cancer Research, New York, NY (US);
Abstract
The invention describes amino acid residues of the Smad2 protein which are important for phosphorylation and activity, and Smad2 polypeptide fragments and biologically functional variants thereof. Included and dominant-negative variants of Smad2 and antibodies relating thereto. Also included are nucleic acids which encode such variants. Antibodies which selectively bind pathway-restricted Smad proteins phosphorylated at the C-terminal tail also are provided. Methods and products for using such nucleic acids and polypeptides also are provided.