The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2002
Filed:
Apr. 21, 2000
Applicant:
Inventors:
Samuel Zalipsky, Redwood City, CA (US);
Alberto A. Gabizon, Jerusalem, IL;
Assignee:
ALZA Corporation, Mountain View, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 ; A61K 3/800 ; C08B 1/100 ; A01N 6/100 ;
U.S. Cl.
CPC ...
A61K 9/127 ; A61K 3/800 ; C08B 1/100 ; A01N 6/100 ;
Abstract
Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.