The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2002
Filed:
Jun. 16, 2000
Applicant:
Inventors:
Mark S. Cushman, West Lafayette, IN (US);
Ankush B. Argade, Indianapolis, IN (US);
Rudiger D. Haugwitz, Bethesda, MD (US);
Rajesh Devraj, Ballwin, MO (US);
Assignee:
Purdue Research Foundation, West Lafayette, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/1365 ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/1365 ; C07D / ; C07D / ;
Abstract
Cytotoxic Michael addition derivatives of brefeldin A are described. Oxidation of thiol addition products of brefeldin A provides the corresponding sulfoxides and sulfones. The sulfoxides exhibited more cytotoxic activity than the corresponding sulfides and sulfones in a variety of human cancer cell lines. Pharmaceutical formulations of the disclosed cytotoxic derivatives are also described.
Quick Actions:
Cushman, Mark. (2002). Brefeldin a derivatives (U.S. Patent No. 6362218). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6362218
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile