The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2002
Filed:
Aug. 16, 1999
Peter Hoogerhout, Bilthoven, NL;
Abstract
A novel method of covalently coupling polysaccharides to other biopolymers is provided, using an amino-thiol linker represented by formula (1): H N—[(CH ) —CHR —CR R —A] —CHR —(CHR ) —CHR —S—R wherein A is a direct bond or a group having the formula —{Z—(CH ) —CHR —CHR R } Z—, m is an integer form 0 to 5; n is an integer form 0 to 3; p is an integer from 0 to 2; q is the integer 0 or 1; R is hydrogen or C -C alkyl, optionally substituted by amino, hydroxyl, carboxyl, C -C alkoxycarbonyl, carbamoyl, mono- or di(C -C alkyl)carbamoyl or N-(&agr;-carboxyalkyl)carbamoyl, or, if m ≠0, R is hydroxyl, amino or peptidylamino; R and R are independently hydrogen or C -C alkyl, or together from an oxo group; R is hydrogen, C -C alkyl, carboxyl, C -C alkoxycarbonyl, carbamoly, mono-or di(C -C alkyl)carbamoyl or N-(&agr;-carboxyalkyl) carbamoyl; R is hydrogen, methyl, hydroxy or C -C acyloxy; R is hydrogen or methyl; R is hydrogen or thiol-protecting group or group having the formula —S—CHR —(CHR ) —CHR —[A—CR R —CHR —(CH ) ] —NH ; and Z is imino, methylimino, oxygen or sulphur.