The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2002
Filed:
May. 10, 2000
Applicant:
Inventors:
Thomas Schupp, Mohlin, CH;
James Madison Ligon, Apex, NC (US);
Istvan Molnar, Durham, NC (US);
Ross Zirkle, Raleigh, NC (US);
Devon Dawn Cyr, Fuquay-Varina, NC (US);
Jörn Görlach, Durham, NC (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/02 ; C12N 1/20 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 9/02 ; C12N 1/20 ; C07H 2/104 ;
Abstract
Nucleic acid molecules are isolated from that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.