The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2002
Filed:
Jul. 12, 1999
James M. Clark, San Mateo, CA (US);
Kyle Elrod, Fremont, CA (US);
Thomas E. Jenkins, LaHonda, CA (US);
Bradley A. Katz, San Francisco, CA (US);
William R. Moore, Burlingame, CA (US);
Robert M. Stroud, San Francisco, CA (US);
Axys Pharmaceuticals, Inc., San Francisco, CA (US);
Abstract
The present invention relates to serine protease inhibitors having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s) and methods for identifying and using the inhibitors. The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and are useful in various processes associated with serine protease isolation and inhibition.