The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2002
Filed:
Jan. 14, 2000
Juliane Beliczey, Bergisch Gladbach, DE;
Udo Kragl, Kritzmow, DE;
Andreas Liese, Jülich, DE;
Christian Wandrey, Jülich, DE;
Kurt Hamacher, Aachen, DE;
Heinz Hubert Coenen, Grevenbroich, DE;
Thomas Tierling, Köln, DE;
Abstract
Furanosides or pyranosides can be reacted with pyruvate and converted into sialic acids in good yields by an enzymatic synthesis, using a suitable aldolase, where the concentration of aldolase, per 50 mM of pyruvate, is 1 to 2,500 U*/ml. For example, 3-fluoroneuraminic acid and other 3,3-didesoxy-3-fluorononulopyranosonic acid derivatives can be prepared in this manner. The F-atom in the resulting sialic acid (which can be F or F and F) provides a label which makes possible studies of mammalian physiology and diagnosis of mammalian diseases.