The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2002
Filed:
Aug. 10, 1999
B. Brett Finlay, Richmond, CA;
Brendan Kenny, Redland, GB;
Markus Stein, Quercegrossa, IT;
Michael S. Donnenberg, Baltimore, MD (US);
Li-Ching Lai, Upper Arlington, OH (US);
University of British Columbia, Vancouver, CA;
Abstract
The present invention provides the EspA polypeptide, which is secreted by pathogenic such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Diagnosis of disease caused by such pathogenic can be performed by standard techniques, such as those based upon the use of antibodies which bind to EspA to detect the protein, as well as those based on the use of nucleic acid probes for detection of nucleic acids encoding EspA protein. The invention also provides isolated nucleic acid sequences encoding EspA, EspA polypeptide, EspA peptides, a method for producing recombinant EspA, antibodies which bind to EspA, and a kit for the detection of EspA-producing The invention also provides a method of immunizing a host with EspA to induce a protective immune response to EspA.