The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2002
Filed:
Mar. 04, 1999
Applicant:
Inventors:
Mikio Niwa, Ibaraki, JP;
Masaji Okamoto, Ibaraki, JP;
Tomoe Matsumoto, Ibaraki, JP;
Toshiaki Segawa, Ibaraki, JP;
Assignee:
Toa Gosei Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/471 ; C07K 1/900 ; C12N 5/10 ; C12N 1/510 ;
U.S. Cl.
CPC ...
C07K 1/471 ; C07K 1/900 ; C12N 5/10 ; C12N 1/510 ;
Abstract
A novel polypeptide is provided, which can be utilized to treat diseases accompanying neovascularization, such as solid tumors, and is useful as a low molecular weight VEGF inhibitor. The polypeptide contains immunoglobulin-like domain 1 and immunoglobulin-like domain 2 of the extracellular domain of the VEGF receptor KDR. Since it has smaller molecular weight than the conventional polypeptides with retaining VEGF inhibitory activity, it is expected that it can be readily expressed using recombinant DNA techniques and infiltrates into diseased sites more quickly.