The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2002
Filed:
Sep. 24, 1998
Applicant:
Inventors:
Daniel J. O'Mahony, Dublin, IE;
Gerard Cagney, Seattle, WA (US);
Assignee:
Elan Corporation, plc, Dublin, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/104 ;
U.S. Cl.
CPC ...
C07H 2/104 ;
Abstract
A composition and method for enhancing paracellular transport across cell layers in an animal comprising an antisense oligonucleotide hybridizable with a region of the messenger RNA coding for the protein occludin which, when hybridized to the occludin mRNA, interferes with its translation such that occludin function is disrupted and paracellular permeability is increased across an epithelial cell layer or and endothelial cell layer in an animal.