The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2002
Filed:
Apr. 02, 1997
Graham P. Allaway, Mohegan Lake, NY (US);
Virginia M. Litwin, Fayetteville, NY (US);
Paul J. Maddon, Elmsford, NY (US);
William C. Olson, Ossining, NY (US);
Progenics Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
This invention provides methods for inhibiting fusion of HIV-1 to CD4 cells which comprise contacting CD cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4 cells is inhibited. This invention also provides methods for inhibiting HIV-1 infection of CD4 cells which comprise contacting CD4 cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4 cells is inhibited, thereby inhibiting the HIV-1 infection. This invention provides non-chemokine agents capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4 cells. This invention also provides pharmaceutical compositions comprising an amount of the non-chemokine agent capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4 cells effective to prevent fusion of HIV-1 to CD4 cells and a pharmaceutically acceptable carrier.