The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2002
Filed:
Mar. 10, 2000
Bernd Buchmann, Hohen Neuendorf, DE;
Wolfgang Frohlich, Berlin, DE;
Claudia Giesen, Berlin, DE;
Hartwig Hennekes, Berlin, DE;
Stefan Jaroch, Berlin, DE;
Werner Skuballa, Berlin, DE;
Schering Aktiengesellschaft, Berlin, DE;
Abstract
The invention relates to leukotriene B derivatives of general formula (I) in which R stands for CH OH, CH , CF , COOR , CONR R ; R stands for H or an organic acid radical with 1-15 C atoms; R stands for H; R is hydrogen, C -C -alkyl, C -C -cycloalkyl, a C -C -aryl radical optionally substituted by 1-3 halogen, phenyl, C -C -alkyl, C -C -alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy, or CH —CO—(C -C ) aryl, or a 5-6 link ring with at least 1 heteroatom; A is a trans-, trans-CH═CH—CH═CH, a —CH CH —CH═CH— or a tetramethylene group; B is a C -C linear or branched-chain aklylene group or the group (a) or (b); D is a direct bonding, oxygen, sulphur, —C≡C—, —CH═CR , or a direct bonding with B. The invention also relates to salts thereof, having physiologically compatible bases and their cyclodextrin clathrates. The inventive substances can be used as pharmaceutical preparations