The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2002
Filed:
Nov. 09, 1999
Applicant:
Inventors:
Stephen Charles Emery, Macclesfield, GB;
David Charles Blakey, Macclesfield, GB;
Assignee:
Zeneca Limited, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 4/800 ; C12N 1/500 ; C12N 1/563 ; C12N 1/588 ;
U.S. Cl.
CPC ...
A61F 4/800 ; C12N 1/500 ; C12N 1/563 ; C12N 1/588 ;
Abstract
The invention provides a gene construct encoding a cell targeting moiety and a heterologous prodrug activating enzyme for use as a medicament in a mammalian host wherein the gene construct is capable of expressing the cell targeting moiety and enzyme as a conjugate within a target cell in the mammalian host and wherein the conjugate is directed to leave the cell thereafter for selective localisation at a cell surface antigen recognised by the cell targeting moiety.