The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 15, 2002
Filed:
Jan. 30, 1996
Applicant:
Inventor:
Mark J. Cooper, Solon, OH (US);
Assignee:
Case Western Reserve University, Cleveland, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/170 ; C12N 1/585 ; C12P 2/102 ;
U.S. Cl.
CPC ...
A61K 3/170 ; C12N 1/585 ; C12P 2/102 ;
Abstract
Episomal plasmids containing a papovavirus origin of replication and a papovavirus large T antigen mutant form are shown to replicate episomally in human cells, and yield levels of gene expression proportional to their episomal copy number. In conjunction with liposomal or receptor-mediated delivery systems, papovavirus-derived episomal plasmids provide an alternative vector for gene therapy, particularly when utilizing strategies requiring high levels of gene expression.